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Methyl-CpG binding domain 2 (Mbd2) is an epigenetic regulator of autism-risk genes and cognition.
Lax E, Do Carmo S, Enuka Y, Sapozhnikov DM, Welikovitch LA, Mahmood N, Rabbani SA, Wang L, Britt JP, Hancock WW, Yarden Y, Szyf M. Lax E, et al. Transl Psychiatry. 2023 Jul 13;13(1):259. doi: 10.1038/s41398-023-02561-9. Transl Psychiatry. 2023. PMID: 37443311 Free PMC article.
Some evidence linked this protein to neurodevelopment. However, its exact role in neurodevelopment and brain function is mostly unknown. Here we show that Mbd2-deficiency in mice (Mbd2-/-) results in deficits in cognitive, social and emotional functions. M …
Some evidence linked this protein to neurodevelopment. However, its exact role in neurodevelopment and brain function is mostly unkno …
Effects of atrazine and chlorpyrifos on DNA methylation in the brain and gonad of the common carp.
Xing H, Wang C, Wu H, Chen D, Li S, Xu S. Xing H, et al. Comp Biochem Physiol C Toxicol Pharmacol. 2015 Feb;168:11-9. doi: 10.1016/j.cbpc.2014.11.002. Epub 2014 Nov 18. Comp Biochem Physiol C Toxicol Pharmacol. 2015. PMID: 25460047
The purpose of the present study was to examine the effect of atrazine (ATR), chlorpyrifos (CPF) and combined ATR/CPF exposure on DNA methylation in the brain and gonad of common carp (Cyprinus carpio L.). The carp were sampled after a 40-d exposure to CPF and ATR, individ …
The purpose of the present study was to examine the effect of atrazine (ATR), chlorpyrifos (CPF) and combined ATR/CPF exposure on DNA methyl …
Early Life Stress and Epigenetics in Late-onset Alzheimer's Dementia: A Systematic Review.
Lemche E. Lemche E. Curr Genomics. 2018 Nov;19(7):522-602. doi: 10.2174/1389202919666171229145156. Curr Genomics. 2018. PMID: 30386171 Free PMC article. Review.
Further considered were the roles of autophagy impairment, neuroinflammation, and brain insulin resistance. For the meta-analytic evaluation, 224 candidate gene loci were extracted from reviews of animal studies of LOAD pathophysiological mechanisms, of which 60 had no pos …
Further considered were the roles of autophagy impairment, neuroinflammation, and brain insulin resistance. For the meta-analytic eva …
Alteration of Scn3a expression is mediated via CpG methylation and MBD2 in mouse hippocampus during postnatal development and seizure condition.
Li HJ, Wan RP, Tang LJ, Liu SJ, Zhao QH, Gao MM, Yi YH, Liao WP, Sun XF, Long YS. Li HJ, et al. Biochim Biophys Acta. 2015 Jan;1849(1):1-9. doi: 10.1016/j.bbagrm.2014.11.004. Epub 2014 Nov 18. Biochim Biophys Acta. 2015. PMID: 25459751
We then demonstrated that the sequence containing -39C was a MBD2-binding motif and the CpG methylation of the promoter region increased the capability of MBD2's binding to the motif. ...In the hippocampus of seizure mice, the expressions of Scn3a and Mbd2 we …
We then demonstrated that the sequence containing -39C was a MBD2-binding motif and the CpG methylation of the promoter region increa …
Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development.
Hendrich B, Guy J, Ramsahoye B, Wilson VA, Bird A. Hendrich B, et al. Genes Dev. 2001 Mar 15;15(6):710-23. doi: 10.1101/gad.194101. Genes Dev. 2001. PMID: 11274056 Free PMC article.
MBD2 and MBD3 are closely related proteins with consensus methyl-CpG binding domains. ...We show by gene targeting that the two proteins are not functionally redundant in mice, as Mbd3-/- mice die during early embryogenesis, whereas Mbd2-/- mice are viable and ferti …
MBD2 and MBD3 are closely related proteins with consensus methyl-CpG binding domains. ...We show by gene targeting that the two prote …
DNA-methyltransferase1 (DNMT1) binding to CpG rich GABAergic and BDNF promoters is increased in the brain of schizophrenia and bipolar disorder patients.
Dong E, Ruzicka WB, Grayson DR, Guidotti A. Dong E, et al. Schizophr Res. 2015 Sep;167(1-3):35-41. doi: 10.1016/j.schres.2014.10.030. Epub 2014 Dec 2. Schizophr Res. 2015. PMID: 25476119 Free PMC article.
The down regulation of glutamic acid decarboxylase67 (GAD1), reelin (RELN), and BDNF expression in brain of schizophrenia (SZ) and bipolar (BP) disorder patients is associated with overexpression of DNA methyltransferase1 (DNMT1) and ten-eleven translocase methylcytosine d …
The down regulation of glutamic acid decarboxylase67 (GAD1), reelin (RELN), and BDNF expression in brain of schizophrenia (SZ) and bi …
MBD2 and MeCP2 regulate distinct transitions in the stage-specific differentiation of olfactory receptor neurons.
Macdonald JL, Verster A, Berndt A, Roskams AJ. Macdonald JL, et al. Mol Cell Neurosci. 2010 May;44(1):55-67. doi: 10.1016/j.mcn.2010.02.003. Epub 2010 Feb 24. Mol Cell Neurosci. 2010. PMID: 20188178
DNA methylation-dependent gene silencing is initiated by DNA methyltransferases (DNMTs) and mediated by methyl-binding domain proteins (MBDs), which recruit histone deacetylases (HDACs) to silence DNA, a process that is essential for normal development. Here, we show that the MBD …
DNA methylation-dependent gene silencing is initiated by DNA methyltransferases (DNMTs) and mediated by methyl-binding domain proteins (MBDs …
Overexpression of MBD2 in glioblastoma maintains epigenetic silencing and inhibits the antiangiogenic function of the tumor suppressor gene BAI1.
Zhu D, Hunter SB, Vertino PM, Van Meir EG. Zhu D, et al. Cancer Res. 2011 Sep 1;71(17):5859-70. doi: 10.1158/0008-5472.CAN-11-1157. Epub 2011 Jul 1. Cancer Res. 2011. PMID: 21724586 Free PMC article.
BAI1 is expressed in normal human brain, but it is frequently silenced in glioblastoma multiforme. ...In glioma cells, treatment with the DNA demethylating agent 5-aza-2'-deoxycytidine (5-Aza-dC) was sufficient to reactivate BAI1 expression. Chromatin immunoprecipitation s …
BAI1 is expressed in normal human brain, but it is frequently silenced in glioblastoma multiforme. ...In glioma cells, treatment with …
Neuronal non-CG methylation is an essential target for MeCP2 function.
Tillotson R, Cholewa-Waclaw J, Chhatbar K, Connelly JC, Kirschner SA, Webb S, Koerner MV, Selfridge J, Kelly DA, De Sousa D, Brown K, Lyst MJ, Kriaucionis S, Bird A. Tillotson R, et al. Mol Cell. 2021 Mar 18;81(6):1260-1275.e12. doi: 10.1016/j.molcel.2021.01.011. Epub 2021 Feb 8. Mol Cell. 2021. PMID: 33561390 Free PMC article.
To test the biological significance of the dual-binding specificity of MeCP2, we replaced its DNA binding domain with an orthologous domain from MBD2, which can only bind mCG motifs. Knockin mice expressing the domain-swap protein displayed severe Rett-syndrome-like phenot …
To test the biological significance of the dual-binding specificity of MeCP2, we replaced its DNA binding domain with an orthologous domain …
Male-transmitted transgenerational effects of the herbicide linuron on DNA methylation profiles in Xenopus tropicalis brain and testis.
Roza M, Eriksson ANM, Svanholm S, Berg C, Karlsson O. Roza M, et al. Sci Total Environ. 2024 May 1;923:170949. doi: 10.1016/j.scitotenv.2024.170949. Epub 2024 Feb 15. Sci Total Environ. 2024. PMID: 38365020 Free article.
Reduced representation bisulfite sequencing (RRBS) revealed numerous differentially methylated regions (DMRs) in brain (3060 DMRs) and testis (2551 DMRs) of the adult male F2 generation. ...DMRs were also identified in several genes central for the machinery that regulates …
Reduced representation bisulfite sequencing (RRBS) revealed numerous differentially methylated regions (DMRs) in brain (3060 DMRs) an …
48 results